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IFSO WC 2017


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Changes in brain activity and behaviour explaining weight loss

The clinical efficacy of bariatric surgery has encouraged the scientific investigation of the gut as a major endocrine organ. Manipulation of gastrointestinal anatomy through surgery has been shown to profoundly affect the physiological and metabolic processes that control body weight and glycaemia.

The most popular bariatric surgical procedures are gastric bypass and sleeve gastrectomy. Even though these procedures were designed with the aim of causing restriction of food intake and nutrient malabsorption, evidence suggests that their contributions to weight loss are minimal. By contrast, these  interventions reduce body weight by decreasing hunger, increasing satiation during a meal, changing food preferences and energy expenditure.

Carel W. Le Roux explains in this lecture the different changes in brain activity and how these mechanisms as well as their mediators can influence weight loss.